A one-week workshop on Design and Shielding Calculation in Medical Radiological Facilities was conducted in Guatemala City from February 5-9, 2018. This is a part of the ongoing RSRP collaboration with the Regulatory Authority designed to strengthen Radiation Protection program in Guatemala. Medical imaging and therapeutic modalities were discussed, for the purposes of shielding calculations and design optimization, with special focus on the Radiation Therapy Practice. NCRP145, NCRP147 and NCRP151 served as baseline guidance, recommendations and technical information for the workshop. Software and other computer tools were provided to the participants to support the shielding calculation process. Practical examples were developed by participants under instructor’s supervision. Participants demonstrated newly acquired knowledge through a test that covered all presented topics.